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Volume 4 Issue 1
January-February 2026
| Author(s) | Nirmala Chandrasekaran, Hasini Hariharan |
|---|---|
| Country | India |
| Abstract | The human gut microbiome, a complex ecosystem of microorganisms residing in the gastrointestinal tract, has emerged as a critical regulator of host health. Its influence extends far beyond digestion to encompass immune function, metabolic balance, and, increasingly, brain-related processes. Diet stands out as the most potent and modifiable environmental factor shaping the composition and, more importantly, the functional activity of this microbial community. This review synthesizes current evidence on how specific dietary components and broader dietary patterns reconfigure the gut microbiome and explores the subsequent implications for host physiology via the microbiota-gut-brain axis. Analysis of mechanistic studies and human clinical trials reveals that dietary changes can induce rapid shifts in microbial gene expression and metabolite production. Long-term adherence to plant-based, fibre-rich, fermented, and Mediterranean-style diets is consistently linked to enhanced microbial diversity, increased production of beneficial short-chain fatty acids (SCFAs), and reduced systemic inflammation. Conversely, Western-style diets high in processed foods, saturated fats, and refined sugars are associated with diminished microbial diversity and unfavourable metabolic outputs. Collectively, the evidence positions diet as a powerful lever for modulating the gut microbiome, with significant potential to influence immune, metabolic, and mental health outcomes. A deeper understanding of these diet-microbiome interactions paves the way for targeted nutritional strategies to promote gut and brain resilience. |
| Keywords | Diet, Gut Microbiota, Gut-brain axis, Microbiome. |
| Discipline | Biology > Medical / Physiology |
| Published In | Volume 4, Issue 1, January-February 2026 |
| Published On | 2026-01-21 |
| DOI | https://doi.org/10.62127/aijmr.2026.v04i01.1172 |
| Short DOI | https://doi.org/hbnwwn |

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