Advanced International Journal of Multidisciplinary Research

E-ISSN: 2584-0487 •   Impact Factor: 9.11

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A Review On: Carboplatin Dose Optimisation by using AUC and Calvert Formula Method

Author(s) Dr. P.S.R.MADHURI CH, Ms. ARSHIYA ANJUM SHEIK, Ms. POOJA SRI CHAMARTHI, Mr. SOUMEN MAL
Country India
Abstract Cancer remains a significant global health challenge, driving the need for enhanced treatment options. Chemotherapy, particularly for advanced stages, is a cornerstone of cancer management. Among the chemotherapeutic agents, platinum-based compounds have demonstrated considerable efficacy. Carboplatin, a second-generation platinum analog of cisplatin, was developed to offer a more favorable safety profile and is employed in the treatment of a variety of malignancies. Its mechanism of action involves the formation of platinum-DNA cross-links, which impede DNA replication and protein synthesis, ultimately leading to cancer cell death. While generally better tolerated than cisplatin, carboplatin can still elicit adverse effects, including myelosuppression and gastrointestinal disturbances.
Renal function is a critical determinant of carboplatin dosage, as the kidneys are the primary route of drug elimination. The Area Under the Curve (AUC) method, employing the Calvert formula, is the standard for individualizing carboplatin doses, aiming to optimize therapeutic benefit while minimizing toxicity. Carboplatin is predominantly used for ovarian cancer but also shows efficacy in lung, head and neck, and bladder cancers.
This review delves into chemotherapy strategies and platinum-based anticancer agents, with a specific focus on carboplatin's characteristics, mechanism of action, dosing principles, and clinical application.
Keywords Area under the Curve, Cancer chemotherapy ,Carboplatin, Calvert formula, Glomerular filtration rate, Platinum-based anticancer agents, Pharmacokinetics, Renal function assessment
Discipline Medical / Pharmacy
Published In Volume 4, Issue 2, March-April 2026
Published On 2026-03-22
DOI https://doi.org/10.62127/aijmr.2026.v04i02.1234
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