Advanced International Journal of Multidisciplinary Research

E-ISSN: 2584-0487 •   Impact Factor: 9.11

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Chronotoxicology and Tridoṣa: How Circadian Rhythms Influence Viṣa Vega

Author(s) Dr. Sankalan Bhattacharya, Dr. Sasanka Shekhar Choudhury
Country India
Abstract Chronobiology has emerged as an important field explaining the physiological and pathological significance of biological rhythms in human health. Chronotoxicology, a branch of chronobiology, studies the time-dependent variations in toxic responses influenced by circadian rhythms. Contemporary evidence suggests that absorption, distribution, metabolism, detoxification and elimination of toxic substances vary according to biological timing. Ayurveda has long recognised temporal variations in physiology through concepts such as Dinacharya, Ritucharya, Doṣa Kāla and Vega dynamics. The present review explored the relationship between chronotoxicology and Tridoṣa with special reference to Viṣa Vega. Classical Ayurvedic texts describe fluctuations in Doṣa predominance across day-night cycles and seasonal transitions, which significantly influence susceptibility, manifestation and progression of toxic conditions. Modern circadian science demonstrates that hepatic enzyme activity, hormonal secretion, gastrointestinal motility, immune responses and neural regulation vary according to circadian oscillations. These mechanisms appear to parallel Ayurvedic descriptions of Doṣika dominance and toxic aggravation at specific time periods. This review analysed classical Ayurvedic literature along with contemporary biomedical evidence to understand how circadian rhythms may influence the onset, severity and progression of poisoning. Databases including PubMed, Scopus, Google Scholar and AYUSH Research Portal were searched for relevant literature published between 2000 and 2026. The review highlighted integrative perspectives connecting biological clocks with Viṣa Vega progression and emphasised the importance of chronotherapeutic strategies in Ayurvedic toxicology. Understanding temporal biology in poisoning may improve diagnostic accuracy, therapeutic timing and individualised management approaches in integrative medicine.
Keywords Chronobiology, Chronotoxicology, Circadian rhythm, Tridoṣa, Viṣa Vega, Agada Tantra, Kriya Shareera
Discipline Biology > Medical / Physiology
Published In Volume 4, Issue 3, May-June 2026
Published On 2026-05-27
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